AID Factor V / II + MTHFR Kit – Detection of risk alleles for thrombosis

• Test results available after approximately 4 hours
• Control bands on each test strip confirm correct DNA isolation, amplification, and hybridization
• Suitable for automated systems
• Evaluation and documentation via the AID scanner and software
• CE IVD

Factor V-Leiden is the most widespread genetic risk factor for deep venous thrombosis in general public. Reason is a SNP in factor V gene which makes the protein resistant against inactivation. Insufficient inactivation of factor V means a higher risk for thrombosis.

Very similar effect is caused by a mutation in regulatory region of prothrombin gene. Here the mutation causes higher synthesis of factor II resulting in more thrombin and therefor higher risk for thrombosis. Hyperhomocysteinemia is another risk factor for cardiovascular disease and deep venous thrombosis. SNPs C677T und A1298C in methylenetetrahydrofolate reductase (MTHFR) gene result in a reduced activity of the enzyme to metabolize homocysteine, which then accumulates.

AID Factor V / II + MTHFR Kit enables detection of risk alleles for thrombosis.