Measurement of the CMV-specific T-cell response

• Automated analysis and documentation with the AID Reader System and analysis software
• High degree of standardization
• CE₀₄₈₃ IVD

Human cytomegalovirus (HCMV), a member of the herpesvirus family, establishes life-long persistence and latency after primary infection as all other Herpesviruses. The sera prevalence in Germany is around 47% for pregnant women and 77% for kidney transplant patients (Source: RKI Epidemiologisches Bulletin 3/2014). Infectious particles can be detected in tear fluid, salvia, urine, genital secretions, breast milk and of course, blood. It can be reactivated later in life and for immunosuppressed patients it is an important pathogen that can cause severe disease. HCMV is also thought to play a causative role in inflammatory diseases and cancer.

HCMV infection induces a humoral and cellular immunresponse. Several studies show that HCMV-specific T cells play an important role in the control of infection.

The AID CMVSpot Assay measures the CMV-specific immune response by detecting CMV specific T cells.