AID Fructose Intolerance Kit – Detection of the 4 most common mutations in the aldolase B gene

• Test results are available after approximately 4 hours
• Control bands on each test strip verify correct DNA isolation, amplification, and hybridization
• Suitable for automation
• Evaluation and documentation are performed using the AID scanner and software
• CE IVD

Hereditary Fructose Intolerance is a rare genetic disorder and inherited as an autosomal recessive trait. Mutations in the gene for the enzyme fructose-1-phosphat aldolase (aldolase B) are causing an inactive form of the enzyme. Patients with inactive aldolase B enzyme show strong accumulation of fructose-1-phosphate and fructose-1,6-bisphosphat in liver, kidney and intestine resulting in intoxication.

Until now there are described about 35 mutations which are inactivating. About 95% of aldolase B deficiency are caused by the four mutations A149P, A174D, N334K and Δ4E4.

AID Fructose Intolerance Kit enables detection of the four most frequent mutations in aldolase B gene.