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Parallel detection of an active immune response and memory response to non-tuberculous mycobacteria (NTM)

Parallel detection of the cytokines IFN-γ and IL-2

  • Detection of an active immune response through IFN-γ
  • Detection of memory T cells by IL-2 detection
  • Ratio of double- and single-stained spots for a differentiated assessment of immune status
  • Automatic evaluation and documentation with the AID Reader System
  • CE IVD

The group of non-tuberculous mycobacteria includes all mycobacteria that do not belong to the M. tuberculosis complex or the M. leprae complex.

NTM are ubiquitous in the environment and are frequently detectable on mucosal surfaces. Distinguishing between colonization and infection is therefore crucial. In the presence of an intact immune response, disease is rather rare. In patients with pre-existing conditions or undergoing immunosuppressive therapy, diseases—especially of the lungs—are described more frequently, and their incidence has increased significantly in recent years.

The AID NTM-iSpot FluoroSpot Assay is suitable for the detection of infection and for the differential diagnosis of tuberculosis by detecting specific effector and memory effector T cells. This enables targeted therapy and minimizes the development of antibiotic resistance.

 

Characteristics

  • Blood collection is performed using standard tubes
  • Detection of an active immune response through IFN-γ
  • Detection of memory T cells by IL-2 detection
  • Ratio of double- and single-stained spots for a differentiated assessment of immune status
  • Automatic evaluation and documentation with the AID Reader System
  • Article No. ELSP 7070 / ELSP 7080
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